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JAK2 v617f

SKU: Z-Path-GT-QU-JAK2-617

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Information

quasa (Quantitative Allele Specific Amplification) for the detection of rare mutations. In cancer, acquired mutations are of diagnostic, prognostic and therapeutic significance. However, these mutations can be present at a very low overall level as a proportion of the total DNA in the sample. quasa kits give specific and sensitive detection down to low copy numbers in the presence of competing wild type DNA. Kits are quantitative and sensitive down to 0.1%. Full details of the quasa method are available in the handbook.

quasa kits are supplied with their own mastermix which is essential for kit performance. 

Packaged, optimised and ready to use. Expect Better Data.

Product Features

Product features

  • Exceptional value for money
  • Rapid detection of all clinically relevant subtypes
  • Positive copy number standard curve for quantification
  • Highly specific detection profile
  • High priming efficiency
  • Broad dynamic detection range (>6 logs)
  • Sensitive to < 100 copies of target
  • Accurate controls to confirm findings

genesig® kits are sold for research use only and are not licensed for diagnostic procedures.

Kit contents:

Primer and multiplex probe mix - wildtype/variants (50 reactions)
Positive controls - wildtype/variants
quasa mastermix (50 reactions)
RNAse/DNAse free water

Ordering

Vaz, D.1. PB2202 VALIDATION OF THE PRIMERDESIGN® QUANTITATIVE ALLELE SPECIFIC AMPLIFICATION KIT FOR THE DETECTION OF THE JAK2V617F MUTATION. HemaSphere 3(S1):p 987, June 2019. | DOI: 10.1097/01.HS9.0000567288.78521.f3

PB2202 VALIDATION OF THE PRIMERDESIGN® QUANTITATIVE ALLELE S... : HemaSphere (lww.com)

Not open access, but looks like they used our kit based on this report: content (wits.ac.za)

Chatambudza M, Skhosana L, Ketseoglou I, Wiggill T. High Risk Janus Kinase 2 V617F Allele Burden in a Seven-Year Cohort of Patients with Myeloproliferative Neoplasms. Clin Lab. 2021 Nov 1;67(11). doi: 10.7754/Clin.Lab.2021.210236. PMID: 34758219.

High Risk Janus Kinase 2 V617F Allele Burden in a Seven-Year Cohort of Patients with Myeloproliferative Neoplasms - PubMed (nih.gov)

Resources

https://journals.lww.com/hemasphere/Abstract/2019/06001/PB2202_VALIDATION_OF_THE_PRIMERDESIGN_.2068.aspx

PB2202 VALIDATION OF THE PRIMERDESIGN® QUANTITATIVE ALLELE SPECIFIC AMPLIFICATION KIT FOR THE DETECTION OF THE JAK2V617F MUTATION

Vaz, D.1

Author Information

HemaSphere 3(S1):p 987, June 2019. | DOI: 10.1097/01.HS9.0000567288.78521.f3

https://journals.lww.com/hemasphere/Abstract/2019/06001/PB2201_PROGRESS_AND_SURVIVAL_IN_TRIPLE_NEGATIVE.2067.aspx

PB2201 PROGRESS AND SURVIVAL IN TRIPLE NEGATIVE PRIMARY MYELOFIBROSIS PATIENTS

Potre, C.1; Borsi, E.1; Samfireag, M.1; Pescaru, M.1; Potre, O.1

Author Information

HemaSphere 3(S1):p 986-987, June 2019. | DOI: 10.1097/01.HS9.0000567284.78521.cc

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